Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.51 |
| ▸ | HTR1A | P08908 | 6/20 | 0.51 |
| ▸ | HTR2A | P28223 | 6/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25003022 | 0.85 | DRD2 (0.53) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL25003037 | 0.82 | DRD2 (0.51) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL25003291 | 0.81 | DRD2 (0.52) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL25003854 | 0.78 | KCNH2 (0.53) | DRD2HTR1AHTR2ADRD3ADRA1A | |
| SCHEMBL20511890 | 0.76 | DRD2 (0.76) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL25003053 | 0.71 | DRD2 (0.65) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL24574054 | 0.71 | DRD2 (0.55) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL7120429 | 0.70 | DRD2 (0.52) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL7127886 | 0.70 | HTR1A (0.52) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL7119957 | 0.69 | DRD2 (0.50) | DRD2HTR1AHTR2ASLC6A4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023011608-A1 | REGULATOR CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海枢境生物科技有限公司 | 2023-02-09 | — | — | WO | disclosed |