Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 9/20 | 0.60 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31280892 | 1.00 | MIF (0.60) | MIFPFKFB3KDM4EALDH1A1HSD17B3 | |
| SCHEMBL15842327 | 0.83 | GLA (0.66) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL250387 | 0.83 | MIF (0.68) | MIFPFKFB3KDM4EALDH1A1HSD17B3 | |
| SCHEMBL2162276 | 0.80 | CA9 (0.65) | MIFPFKFB3KDM4EALDH1A1HSD17B3 | |
| SCHEMBL18141852 | 0.80 | POLB (0.59) | MIFPFKFB3KDM4EALDH1A1HSD17B3 | |
| SCHEMBL210314 | 0.80 | POLB (0.63) | KDM4EALDH1A1POLBMEN1KMT2A | |
| Water SCHEMBL28341685 | 0.78 | POLB (0.61) | KDM4EALDH1A1POLBGLAMAPT | |
| SCHEMBL220708 | 0.78 | HSD17B3 (0.65) | MIFPFKFB3KDM4EALDH1A1HSD17B3 | |
| SCHEMBL30405545 | 0.78 | HSD17B3 (0.65) | MIFPFKFB3KDM4EALDH1A1HSD17B3 | |
| SCHEMBL8764982 | 0.77 | POLB (0.57) | MIFPFKFB3KDM4EALDH1A1HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000881-A1 | CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2012-01-05 | — | — | WO | disclosed |