Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30224827 | 1.00 | ESR1 (0.40) | ESR1SLC22A12GRM4CNR1HTR3A | |
| SCHEMBL22152002 | 0.82 | SLC22A12 (0.38) | SLC22A12GRM4CNR1CYP11B2PDGFRA | |
| SCHEMBL21491067 | 0.80 | GRM2 (0.36) | SLC22A12GRM4CNR1IDO1 | |
| SCHEMBL30224924 | 0.79 | ESR1 (0.45) | ESR1PDGFRACDK5TYRO3KDM4C | |
| SCHEMBL23993249 | 0.79 | ESR1 (0.45) | ESR1PDGFRACDK5TYRO3KDM4C | |
| SCHEMBL23994535 | 0.77 | ESR1 (0.44) | ESR1CYP11B2PDGFRACDK5TYRO3 | |
| SCHEMBL31636216 | 0.77 | PDGFRA (0.48) | ESR1PDGFRACDK5TYRO3KDM4C | |
| SCHEMBL23993327 | 0.77 | ESR1 (0.44) | ESR1SLC22A12PDGFRACDK5TYRO3 | |
| SCHEMBL30224393 | 0.77 | ESR1 (0.44) | ESR1CYP11B2PDGFRACDK5TYRO3 | |
| SCHEMBL30224397 | 0.77 | ESR1 (0.44) | ESR1CYP11B2PDGFRACDK5TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| CN-115698009-A | CD73 inhibiting 2,4-dioxopyrimidine compounds | 吉利德科学公司 | 2023-02-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | ENTPD5, ENTPD1, NT5E | ESR1 1651/4885SLC22A12 1740/4885GRM4 2641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.