Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 5/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.31 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25005491 | 0.80 | ESR1 (0.40) | SLC22A12CNR1GRM4IDO1 | |
| SCHEMBL30224827 | 0.80 | ESR1 (0.40) | SLC22A12CNR1GRM4IDO1 | |
| SCHEMBL21490971 | 0.79 | GRM2 (0.33) | GRM2JAK2JAK1TYK2SLC2A1 | |
| SCHEMBL21464819 | 0.76 | GRM2 (0.43) | GRM2HTR7CNR1CNR2 | |
| SCHEMBL30608179 | 0.76 | GRM2 (0.43) | GRM2HTR7CNR1CNR2 | |
| SCHEMBL17678224 | 0.73 | GRM2 (0.47) | GRM2SLC22A12HTR7CNR1GRM4 | |
| SCHEMBL22152002 | 0.71 | SLC22A12 (0.38) | SLC22A12HTR7CNR1GRM4 | |
| SCHEMBL1964490 | 0.69 | KDM4C (0.41) | GRM2CNR1SLC2A1SLC2A2SLC2A3 | |
| SCHEMBL20752755 | 0.69 | SLC22A12 (0.49) | SLC22A12GRM4 | |
| SCHEMBL11975946 | 0.69 | SLC22A12 (0.66) | SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108463458-B | Modulators of ROR-gamma | 生命医药有限责任公司 | 2022-02-01 | — | — | CN | disclosed |
| US-11008340-B2 | Modulators of ROR-gamma | VITAE PHARMACEUTICALS, LLC (US) | 2021-05-18 | — | — | US | disclosed |
| EP-3377482-B1 | MODULATORS OF ROR-GAMMA | VITAE PHARMACEUTICALS LLC (US) | 2021-05-12 | — | — | EP | disclosed |
| US-20190322687-A1 | MODULATORS OF ROR-GAMMA | VITAE PHARMACEUTICALS, LLC (US) | 2019-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11008340-B2 | Modulators of ROR-gamma | RORC, RORB, RORA | GRM2 545/4885JAK2 272/4885JAK1 329/4885 |
| US-20190322687-A1 | MODULATORS OF ROR-GAMMA | RORC, RORB, RORA | GRM2 545/4885JAK2 272/4885JAK1 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.