Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KYNU | Q16719 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10013089 | 1.00 | LMNA (0.49) | LMNAHIF1AKDM4EKYNUADRB1 | |
| SCHEMBL2501303 | 1.00 | LMNA (0.49) | LMNAHIF1AKDM4EKYNUADRB1 | |
| SCHEMBL10013090 | 1.00 | LMNA (0.49) | LMNAHIF1AKDM4EKYNUADRB1 | |
| SCHEMBL16871060 | 0.88 | ADRB1 (0.42) | LMNAHIF1AKDM4EKYNUADRB1 | |
| SCHEMBL16871044 | 0.88 | ADRB1 (0.42) | LMNAHIF1AKDM4EKYNUADRB1 | |
| SCHEMBL16871243 | 0.87 | LMNA (0.40) | LMNAHIF1AKDM4EKYNUADRB1 | |
| SCHEMBL16871055 | 0.87 | LMNA (0.40) | LMNAHIF1AKDM4EKYNUADRB1 | |
| SCHEMBL16871496 | 0.86 | ADRB1 (0.45) | LMNAHIF1AKDM4EKYNUADRB1 | |
| SCHEMBL16871645 | 0.86 | ADRB1 (0.45) | LMNAHIF1AKDM4EKYNUADRB1 | |
| SCHEMBL11071174 | 0.83 | LMNA (0.53) | LMNAKDM4EALDH1A1PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030354-B2 | 2-(5,5-Dimethylcyclopent-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; metabolic disorders such as type II diabetes | AMGEN INC. (US) | 2011-10-04 | — | — | US | disclosed |