Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.49 |
| ▸ | PLG | P00747 | 4/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.49 |
| ▸ | F2 | P00734 | 3/20 | 0.49 |
| ▸ | F10 | P00742 | 6/20 | 0.46 |
| ▸ | PLAT | P00750 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25015851 | 0.91 | PLG (0.47) | PLAUPLGKLKB1PRSS1F2 | |
| SCHEMBL25017267 | 0.91 | PRSS1 (0.47) | PLAUPLGKLKB1PRSS1F2 | |
| SCHEMBL25015847 | 0.90 | PLG (0.47) | PLAUPLGKLKB1PRSS1F2 | |
| SCHEMBL25017317 | 0.89 | PRSS1 (0.47) | PLAUPLGKLKB1PRSS1F2 | |
| SCHEMBL25015845 | 0.88 | F10 (0.55) | PLAUPLGKLKB1PRSS1F2 | |
| SCHEMBL21822169 | 0.87 | MAPT (0.52) | PLAUPLGKLKB1PRSS1F2 | |
| SCHEMBL25015710 | 0.85 | KCNQ3 (0.46) | PLAUPLGKLKB1PRSS1F2 | |
| SCHEMBL25016725 | 0.85 | F10 (0.44) | PLAUPLGKLKB1PRSS1F2 | |
| SCHEMBL25015697 | 0.85 | ECE1 (0.42) | PLAUPLGKLKB1PRSS1F2 | |
| SCHEMBL25016773 | 0.84 | PLG (0.47) | PLAUPLGKLKB1PRSS1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | MMP7, MATR3, SPINT2 | PLAU 93/4885PLG 225/4885KLKB1 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.