Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 4/20 | 0.47 |
| ▸ | PLAU | P00749 | 4/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.47 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 7/20 | 0.44 |
| ▸ | PLAT | P00750 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25015851 | 0.99 | PLG (0.47) | PLGPLAUKLKB1PRSS1F2 | |
| SCHEMBL25015709 | 0.90 | PLAU (0.49) | PLGPLAUKLKB1PRSS1F2 | |
| SCHEMBL21822273 | 0.90 | NPC1 (0.43) | PLGPLAUKLKB1PRSS1F2 | |
| SCHEMBL21822390 | 0.89 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL21822393 | 0.89 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL25016691 | 0.89 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL25017267 | 0.88 | PRSS1 (0.47) | PLGPLAUKLKB1PRSS1F2 | |
| SCHEMBL25016161 | 0.88 | F10 (0.58) | KLKB1F2F10 | |
| SCHEMBL25016067 | 0.88 | KMT2A (0.44) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL30180643 | 0.88 | KMT2A (0.44) | NPC1RAB9ASMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | MMP7, MATR3, SPINT2 | PLG 225/4885PLAU 93/4885KLKB1 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.