Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4305407 | 0.85 | ALDH1A1 (0.60) | ALDH1A1TDP1NPC1RAB9ARECQL | |
| Hydrazine SCHEMBL28200090 | 0.82 | ALDH1A1 (0.53) | ALDH1A1TDP1NPC1RAB9ARECQL | |
| SCHEMBL4102754 | 0.81 | ALDH1A1 (0.61) | ALDH1A1TDP1NPC1RAB9ARECQL | |
| SCHEMBL31443947 | 0.81 | ALDH1A1 (0.56) | ALDH1A1TDP1NPC1RAB9ARECQL | |
| SCHEMBL3943250 | 0.81 | ALDH1A1 (0.56) | ALDH1A1TDP1NPC1RAB9ARECQL | |
| SCHEMBL2333531 | 0.81 | ALDH1A1 (0.56) | ALDH1A1TDP1NPC1RAB9ARECQL | |
| SCHEMBL3943254 | 0.81 | ALDH1A1 (0.56) | ALDH1A1TDP1NPC1RAB9ARECQL | |
| SCHEMBL27494789 | 0.80 | ALDH1A1 (0.59) | ALDH1A1TDP1NPC1RAB9ARECQL | |
| 2-Nitroanisole SCHEMBL1630291 | 0.80 | ALDH1A1 (0.82) | ALDH1A1TDP1NPC1RAB9ARECQL | |
| SCHEMBL7596299 | 0.79 | ALDH1A1 (0.58) | ALDH1A1TDP1NPC1RAB9ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030296-B2 | Oestrogen-17-sulphamates as inhibitors of steroid sulphatase | STERIX LIMITED (GB) | 2011-10-04 | — | — | US | disclosed |
| US-20070021624-A1 | Steroid sulphatase inhibitors | REED MICHAEL J | 2007-01-25 | — | — | US | disclosed |
| US-20070021624-A1 | Steroid sulphatase inhibitors | REED MICHAEL J | 2007-01-25 | — | — | US | disclosed |
| US-20070021624-A1 | Steroid sulphatase inhibitors | REED MICHAEL J | 2007-01-25 | — | — | US | disclosed |
| US-20060281719-A1 | Oestrogen-17-sulphamates as inhibitors of steroid sulphatase | LLOYD POTTER BARRY V | 2006-12-14 | — | — | US | disclosed |
| US-7119081-B2 | Oestrogen-17-sulphamates as inhibitors of steroid sulphatase | STERIX LIMITED (GB) | 2006-10-10 | — | — | US | disclosed |
| US-7098199-B2 | Steroid sulphatase inhibitors | STERIX LIMITED (GB) | 2006-08-29 | — | — | US | disclosed |
| US-6903084-B2 | Steroid sulphatase inhibitors | STERIX LIMITED (GB) | 2005-06-07 | — | — | US | disclosed |
| US-6677325-B2 | CONTROLLING ESTROGEN PRODUCTION WITH SULFATED STEROIDS | STERIX LTD. (GB) | 2004-01-13 | — | — | US | disclosed |
| US-6642397-B1 | Purified polycyclic sulfamate derivative | STERIX LIMITED (GB) | 2003-11-04 | — | — | US | disclosed |
| US-6476011-B1 | Methods for introducing an estrogenic compound | STERIX LIMITED (GB) | 2002-11-05 | — | — | US | disclosed |
| US-20020128243-A1 | Steroid sulphatase inhibitors | REED MICHAEL JOHN (GB) | 2002-09-12 | — | — | US | disclosed |
| US-20010018435-A1 | Steroid sulphatase inhibitors | STERIX LIMITED | 2001-08-30 | — | — | US | disclosed |
| US-6187766-B1 | Steroid sulphatase inhibitors | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY & MEDICINE (GB) | 2001-02-13 | — | — | US | disclosed |
| US-6159960-A | Steroid sulphatase inhibitors | STERIX LIMITED (GB) | 2000-12-12 | — | — | US | disclosed |
| US-6011024-A | A RING SYSTEM COMPOUND TO WHICH IS ATTACHED A SULPHAMATE GROUP | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY & MEDICINE (GB) | 2000-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021624-A1 | Steroid sulphatase inhibitors | STS, CYP21A2, SULT1E1 | ALDH1A1 365/4885TDP1 3877/4885NPC1 1937/4885 |
| US-20060281719-A1 | Oestrogen-17-sulphamates as inhibitors of steroid sulphatase | STS, SULT1E1, HSD17B11 | ALDH1A1 2655/4885TDP1 1568/4885NPC1 4726/4885 |
| US-20010018435-A1 | Steroid sulphatase inhibitors | STS, CYP21A2, SULT1E1 | ALDH1A1 326/4885TDP1 1788/4885NPC1 2660/4885 |
| US-20020128243-A1 | Steroid sulphatase inhibitors | STS, SULT1E1, CYP21A2 | ALDH1A1 398/4885TDP1 3697/4885NPC1 2065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.