Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.35 |
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10774082 | 0.80 | HRH4 (0.51) | HRH4 | |
| SCHEMBL25697407 | 0.78 | HRH4 (0.54) | HRH4 | |
| SCHEMBL26789070 | 0.74 | HRH4 (0.45) | HRH4PROKR1 | |
| SCHEMBL23114440 | 0.73 | CDK1 (0.45) | HRH4PROKR1 | |
| SCHEMBL17998799 | 0.69 | HRH4 (0.57) | HRH4 | |
| SCHEMBL19468823 | 0.68 | HRH4 (0.47) | HRH4PROKR1 | |
| SCHEMBL807537 | 0.68 | CHEK1 (0.47) | — | |
| SCHEMBL29529805 | 0.68 | HRH4 (0.51) | HRH4 | |
| SCHEMBL22601452 | 0.66 | HRH4 (0.52) | HRH4 | |
| SCHEMBL19468876 | 0.66 | CYP17A1 (0.46) | HRH4PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | DISC MEDICINE, INC. | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230043159-A1 | MATRIPTASE 2 INHIBITORS AND USES THEREOF | MMP7, MATR3, SPINT2 | HRH4 3109/4885KDM5A 721/4885PROKR1 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.