Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.54 |
| ▸ | CHKA | P35790 | 1/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.43 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.39 |
| ▸ | S100B | P04271 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10774082 | 0.98 | HRH4 (0.51) | HRH4CHKALNPEPELOVL1TERT | |
| SCHEMBL29529805 | 0.87 | HRH4 (0.51) | HRH4CHKALNPEPELOVL1TERT | |
| SCHEMBL17998799 | 0.85 | HRH4 (0.57) | HRH4MEN1GAAMAPTMAPK1 | |
| SCHEMBL22601452 | 0.84 | HRH4 (0.52) | HRH4CHKALNPEPELOVL1TERT | |
| SCHEMBL807537 | 0.83 | CHEK1 (0.47) | MEN1ALDH1A1LMNAMAPTALOX15 | |
| SCHEMBL23114440 | 0.81 | CDK1 (0.45) | HRH4MAPTLRRK2 | |
| SCHEMBL22601447 | 0.79 | CHEK1 (0.50) | MEN1LMNAGAAMAPTALOX15 | |
| SCHEMBL25017248 | 0.78 | HRH4 (0.44) | HRH4 | |
| SCHEMBL11960306 | 0.77 | LRRK2 (0.45) | HRH4TERTALDH1A1ALOX15HTT | |
| SCHEMBL9455784 | 0.77 | HRH4 (0.58) | HRH4CHKALNPEPELOVL1TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | PIR, CYP3A43, CYP1A2 | HRH4 1830/4885CHKA 2909/4885LNPEP 4220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.