SCHEMBL25025569

SCHEMBL25025569

Cc1nc(C(F)(F)F)sc1CCO

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SRC P12931 2/20 0.39
ZAP70 P43403 2/20 0.39
SYK P43405 2/20 0.39
PPARD Q03181 3/20 0.38
PPARA Q07869 3/20 0.38
FBP1 P09467 2/20 0.35
CYP1A2 P05177 1/20 0.35
HRH2 P25021 1/20 0.35
HRH1 P35367 1/20 0.35
HRH4 Q9H3N8 1/20 0.35
TKT P29401 5/20 0.35
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.32
PPARG P37231 1/20 0.31
TRPV1 Q8NER1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15211249 0.85 PPARD (0.39) PPARDPPARA
SCHEMBL25164661 0.79 PPARD (0.37) PPARDPPARACYP1A2HRH2HRH1
SCHEMBL18995148 0.78
SCHEMBL279555 0.77 PPARD (0.35) PPARDPPARACYP1A2HRH2HRH1
SCHEMBL27640709 0.77 PPARD (0.36) PPARDPPARAMAPT
SCHEMBL261442 0.74 SRC (0.47) SRCZAP70SYKCYP1A2HRH2
SCHEMBL263398 0.74 ALDH1A1 (0.45) SRCZAP70SYKFBP1CYP1A2
SCHEMBL18995147 0.74
Iodide SCHEMBL28449438 0.72 ALDH1A1 (0.44) SRCZAP70SYKFBP1CYP1A2
SCHEMBL22190217 0.72 CYP1A2 (0.39) SRCZAP70SYKFBP1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4384503-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM Due, Inc. (US) 2024-06-19 EP disclosed
CN-118119595-A Compounds and compositions for the treatment of diseases associated with STING activity 艾福姆德尤股份有限公司 2024-05-31 CN disclosed
US-20230167057-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-06-01 US disclosed
WO-2023018781-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2023-02-16 WO disclosed
WO-2023018781-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2023-02-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230167057-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 SRC 1608/4885ZAP70 354/4885SYK 727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.