SCHEMBL25028765

SCHEMBL25028765

Cc1nc(-c2c[nH]c3c(C#N)cccc23)ccc1NC1CCNC1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CCNT1 O60563 11/20 0.52
▸ CCNK O75909 11/20 0.52
▸ CCNE1 P24864 11/20 0.52
▸ CDK2 P24941 11/20 0.52
▸ CDK9 P50750 11/20 0.52
▸ CDK12 Q9NYV4 11/20 0.52
▸ GSK3B P49841 2/20 0.47
▸ DYRK1A Q13627 2/20 0.47
▸ NFATC1 O95644 1/20 0.47
▸ CDK7 P50613 9/20 0.42
▸ CCNH P51946 9/20 0.42
▸ MNAT1 P51948 7/20 0.42
▸ BRD4 O60885 2/20 0.39
▸ ATAD2 Q6PL18 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL29364340 0.91 CCNT1 (0.51) CCNT1CCNKCCNE1CDK2CDK9
SCHEMBL25028778 0.87 CCNT1 (0.53) CCNT1CCNKCCNE1CDK2CDK9
SCHEMBL29361385 0.87 CCNT1 (0.53) CCNT1CCNKCCNE1CDK2CDK9
SCHEMBL29363471 0.83 GSK3B (0.47) CCNT1CCNKCCNE1CDK2CDK9
SCHEMBL25027526 0.83 GSK3B (0.47) CCNT1CCNKCCNE1CDK2CDK9
SCHEMBL26718510 0.82 DYRK1A (0.45) CCNT1CCNKCCNE1CDK2CDK9
SCHEMBL25027665 0.82 CCNT1 (0.60) CCNT1CCNKCCNE1CDK2CDK9
SCHEMBL25029015 0.82 GSK3B (0.47) CCNT1CCNKCCNE1CDK2CDK9
SCHEMBL25027641 0.81 CCNT1 (0.47) CCNT1CCNKCCNE1CDK2CDK9
SCHEMBL25029171 0.80 DYRK1A (0.58) CCNT1CCNKCCNE1CDK2CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348439-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2023-11-02 — — US disclosed
US-20230348439-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2023-11-02 — — US disclosed
US-11667624-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2023-06-06 — — US disclosed
US-11667624-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2023-06-06 — — US disclosed
CN-115996926-A Indole compounds as androgen receptor modulators 尼多生物科学有限公司 2023-04-21 — — CN disclosed
US-20230049406-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2023-02-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230049406-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 CCNT1 2902/4885CCNK 2842/4885CCNE1 3298/4885
US-20230348439-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 CCNT1 2934/4885CCNK 2738/4885CCNE1 3371/4885
US-11667624-B2 Indole compounds as androgen receptor modulators AR, FSHR, ADRB3 CCNT1 3119/4885CCNK 3289/4885CCNE1 3548/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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