Sugi Predict

Sugi Predict / Compounds / SCHEMBL25029073

SCHEMBL25029073

SCHEMBL25029073

CC(=O)N1CCC(Oc2ncc(-c3c[nH]c4c(C#N)cccc34)nc2C(F)(F)F)C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BTK Q06187 1/20 0.41
▸ CCNK O75909 2/20 0.39
▸ CDK12 Q9NYV4 2/20 0.39
▸ CCNT1 O60563 1/20 0.39
▸ CCNE1 P24864 1/20 0.39
▸ CDK2 P24941 1/20 0.39
▸ CDK9 P50750 1/20 0.39
▸ NFATC1 O95644 1/20 0.39
▸ GSK3B P49841 1/20 0.39
▸ DYRK1A Q13627 1/20 0.39
▸ CYP11B1 P15538 1/20 0.37
▸ CYP11B2 P19099 1/20 0.37
▸ CDK7 P50613 2/20 0.37
▸ CCNH P51946 2/20 0.37
▸ MNAT1 P51948 2/20 0.37
▸ CDK1 P06493 1/20 0.37
▸ CCNB1 P14635 1/20 0.37
▸ FLT3 P36888 1/20 0.37
▸ PIK3CD O00329 8/20 0.37
▸ PIK3CA P42336 7/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29361305 1.00 BTK (0.41) BTKCCNKCDK12CCNT1CCNE1
SCHEMBL29364621 0.90 BTK (0.43) BTKNFATC1GSK3BDYRK1ACYP11B1
SCHEMBL26717704 0.90 BTK (0.43) BTKNFATC1GSK3BDYRK1ACYP11B1
SCHEMBL25028882 0.90 BTK (0.43) BTKNFATC1GSK3BDYRK1ACYP11B1
SCHEMBL26719030 0.90 BTK (0.43) BTKNFATC1GSK3BDYRK1ACYP11B1
SCHEMBL25028656 0.88 NFATC1 (0.40) BTKCCNKCDK12CCNT1CCNE1
SCHEMBL29362053 0.88 BTK (0.44) BTKNFATC1GSK3BDYRK1ACYP11B1
SCHEMBL25029306 0.88 BTK (0.42) BTKNFATC1GSK3BDYRK1ACYP11B1
SCHEMBL29364633 0.88 NFATC1 (0.40) BTKCCNKCDK12CCNT1CCNE1
SCHEMBL25028902 0.88 BTK (0.44) BTKNFATC1GSK3BDYRK1ACYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348439-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2023-11-02 — — US disclosed
US-11667624-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2023-06-06 — — US disclosed
US-11667624-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2023-06-06 — — US disclosed
CN-115996926-A Indole compounds as androgen receptor modulators 尼多生物科学有限公司 2023-04-21 — — CN disclosed
US-20230049406-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES, INC. 2023-02-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230049406-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 BTK 4808/4885CCNK 2842/4885CDK12 1192/4885
US-20230348439-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS AR, FSHR, NR5A1 BTK 4750/4885CCNK 2738/4885CDK12 1168/4885
US-11667624-B2 Indole compounds as androgen receptor modulators AR, FSHR, ADRB3 BTK 4765/4885CCNK 3289/4885CDK12 1193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback