Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28774060 | 0.88 | ALDH1A1 (0.57) | GAAKDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL25363482 | 0.88 | ALDH1A1 (0.57) | GAAKDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL2224391 | 0.88 | ALDH1A1 (0.57) | GAAKDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL2030080 | 0.86 | GAA (0.55) | GAAKDM4ESMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL30793930 | 0.86 | ALDH1A1 (0.51) | KDM4ESMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL3938968 | 0.84 | GAA (0.48) | GAAKDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL15376451 | 0.83 | SMN1; SMN2 (0.40) | GAAKDM4ESMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL2875954 | 0.82 | NOTUM (0.46) | ALDH1A1LMNA | |
| SCHEMBL652433 | 0.82 | NOTUM (0.46) | ALDH1A1LMNA | |
| SCHEMBL2875175 | 0.82 | NOTUM (0.46) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365339-A1 | NOVEL FERROPORTIN INHIBITORS | Vifor (International) AG (CH) | 2018-08-29 | — | — | EP | disclosed |
| WO-2017068090-A1 | NOVEL FERROPORTIN INHIBITORS | VIFOR (INTERNATIONAL) AG (CH) | 2017-04-27 | — | — | WO | disclosed |
| EP-2375904-B1 | BIARYL CARBOXAMIDES | MERCK SHARP & DOHME (US) | 2014-05-28 | — | — | EP | disclosed |
| EP-2375904-A1 | BIARYL CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010077624-A1 | BIARYL CARBOXAMIDES | MERCK SHARP & DOHME CORP. (US) | 2010-07-08 | — | — | WO | disclosed |