Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | WRN | Q14191 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30039096 | 0.96 | MAPT (0.43) | MAPTSMN1; SMN2ALDH1A1ESR2NPC1 | |
| SCHEMBL30038932 | 0.93 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1ESR2NPC1 | |
| SCHEMBL25037077 | 0.91 | MAPT (0.45) | MAPTSMN1; SMN2ALDH1A1ESR2NPC1 | |
| SCHEMBL31005804 | 0.90 | KDM4E (0.39) | MAPTSMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL30037825 | 0.89 | WRN (0.51) | MAPTSMN1; SMN2ALDH1A1ESR2NPC1 | |
| SCHEMBL31499880 | 0.89 | WRN (0.48) | MAPTALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL25035198 | 0.89 | TRPV1 (0.40) | MAPTSMN1; SMN2ALDH1A1ESR2NPC1 | |
| SCHEMBL25035228 | 0.86 | KDM4E (0.40) | MAPTLMNAMEN1TSHRKMT2A | |
| SCHEMBL30037486 | 0.85 | MAPT (0.40) | MAPTSMN1; SMN2ALDH1A1ESR2NPC1 | |
| SCHEMBL31499690 | 0.85 | MAPT (0.42) | MAPTSMN1; SMN2ALDH1A1ESR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230046859-A1 | Bicyclic Compounds and their Uses | NOVARTIS PHARMA AG (CH) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230046859-A1 | Bicyclic Compounds and their Uses | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C1R, F12 | MAPT 2519/4885SMN1; SMN2 3639/4885ALDH1A1 2542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.