Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | WRN | Q14191 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25036710 | 0.90 | MAPT (0.47) | KDM4EWRNTRPV1LMNAMAPT | |
| SCHEMBL25035228 | 0.89 | KDM4E (0.40) | KDM4EFPR2POLBCA1CA2 | |
| SCHEMBL27380712 | 0.88 | MCHR1 (0.40) | KDM4EEPHX2FPR2ENPP2WRN | |
| SCHEMBL27381226 | 0.87 | ENPP2 (0.41) | ENPP2WRNTRPV1AKR1B1LMNA | |
| SCHEMBL27381050 | 0.87 | TP53 (0.41) | KDM4EEPHX2FPR2ENPP2WRN | |
| SCHEMBL27381122 | 0.86 | EPHX2 (0.38) | KDM4EEPHX2FPR2ENPP2WRN | |
| SCHEMBL30039096 | 0.86 | MAPT (0.43) | KDM4EFPR2WRNTRPV1LMNA | |
| SCHEMBL27380972 | 0.85 | ENPP2 (0.39) | KDM4EEPHX2FPR2ENPP2WRN | |
| SCHEMBL27380782 | 0.85 | EPHX2 (0.42) | KDM4EEPHX2ENPP2WRNTRPV1 | |
| SCHEMBL27380708 | 0.85 | WRN (0.45) | KDM4EEPHX2FPR2ENPP2WRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4619104-A1 | BICYCLIC HETEROCYCLES AND THEIR USE AS WRN INHIBITORS | Novartis AG (CH) | 2025-09-24 | — | — | EP | disclosed |
| WO-2024105553-A1 | BICYCLIC HETEROCYCLES AND THEIR USE AS WRN INHIBITORS | NOVARTIS AG (CH) | 2024-05-23 | — | — | WO | disclosed |