Ethyl Fumarate

Ethyl Fumarate

SCHEMBL250400

C=CC(=O)OCCCC.C=Cc1ccccc1.CCOC(=O)C=CC(=O)O.N#CC=C=O

nearest known ligand 0.46

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Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 7/20 0.46
HPGD P15428 1/20 0.42
TSHR P16473 1/20 0.42
ATM Q13315 1/20 0.39
APP P05067 2/20 0.36
THRB P10828 2/20 0.36
MAPT P10636 5/20 0.35
LMNA P02545 3/20 0.35
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
MDM4 O15151 1/20 0.33
MDM2 Q00987 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL251175 0.91 TSHR (0.51) HCAR2HPGDTSHRATMAPP
Ethyl Fumarate SCHEMBL250119 0.90 HCAR2 (0.57) HCAR2HPGDTSHRATMAPP
Butyl Fumarate SCHEMBL3956267 0.87 HCAR2 (0.61) HCAR2HPGDTSHRATMAPP
Butyl Fumarate SCHEMBL3956264 0.87 HCAR2 (0.61) HCAR2HPGDTSHRATMAPP
Styrene SCHEMBL1696568 0.86 TSHR (0.46) HCAR2HPGDTSHRATMAPP
Styrene SCHEMBL7672043 0.86 TSHR (0.41) HPGDTSHRAPPTHRBMAPT
Styrene SCHEMBL5698366 0.84 TSHR (0.59) HCAR2HPGDTSHRATMAPP
Styrene SCHEMBL5698364 0.84 TSHR (0.59) HCAR2HPGDTSHRATMAPP
Butyl Fumarate SCHEMBL10908635 0.83 HCAR2 (0.57) HCAR2HPGDTSHRATMAPP
Ethyl Fumarate SCHEMBL1064537 0.83 HCAR2 (0.55) HCAR2HPGDTSHRAPPTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090053644-A1 CORE-SHELL POLYMER NANOPARTICLES AND METHOD FOR MAKING EMULSION AGGREGATION PARTICLES USING SAME XEROX CORPORATION (US) 2009-02-26 US claimed
US-20090035686-A1 CORE-SHELL POLYMER NANOPARTICLES AND METHOD OF MAKING EMULSION AGGREGATION PARTICLES USING SAME XEROX CORPORATION (US) 2009-02-05 US claimed
US-7291437-B2 Toner processes XEROX CORPORATION (US) 2007-11-06 US claimed
US-7001702-B2 Toner processes XEROX CORPORATION (US) 2006-02-21 US claimed
US-20050048389-A1 Toner processes XEROX CORPORATION 2005-03-03 US claimed
US-6841329-B2 Preparation of toner compositions by a chemical process, such as emulsion aggregation, wherein latex particles are aggregated with a colorant, and optional components, such as a wax XEROX CORPORATION (US) 2005-01-11 US claimed
US-20040202951-A1 Toner processes XEROX CORPORATION 2004-10-14 US claimed
US-20040202952-A1 Toner processes XEROX CORPORATION 2004-10-14 US claimed
US-20040202950-A1 Toner processes XEROX CORPORATION. 2004-10-14 US claimed
US-6803166-B2 Toner processes XEROX CORPORATION 2004-10-12 US claimed
US-20040162373-A1 Toner processes XEROX CORPORATION 2004-08-19 US claimed
US-9045651-B2 Antifouling surfaces, methods of manufacture thereof and articles comprising the same UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-06-02 US disclosed
US-8841055-B2 Super low melt emulsion aggregation toners comprising a trans-cinnamic di-ester XEROX CORPORATION (US) 2014-09-23 US disclosed
US-20130266896-A1 SUPER LOW MELT EMULSION AGGREGATION TONERS COMPRISING A TRANS-CINNAMIC DI-ESTER XEROX CORPORATION (US) 2013-10-10 US disclosed
EP-2028550-B1 Method for making emulsion aggregation particles using core-shell polymer nanoparticles XEROX CORP (US) 2012-08-15 EP disclosed
EP-1736833-A1 Toner and developer compositions Xerox Corporation (US) 2006-12-27 EP disclosed
US-7001702-B2 Toner processes XEROX CORPORATION (US) 2006-02-21 US disclosed
US-20050048389-A1 Toner processes XEROX CORPORATION 2005-03-03 US disclosed
US-6803166-B2 Toner processes XEROX CORPORATION 2004-10-12 US disclosed
US-20040162373-A1 Toner processes XEROX CORPORATION 2004-08-19 US disclosed