Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.56 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL5698364 | 1.00 | TSHR (0.59) | TSHRHPGDHCAR2THRBATM | |
| Butyl Fumarate SCHEMBL3956264 | 0.97 | HCAR2 (0.61) | TSHRHPGDHCAR2THRBATM | |
| Butyl Fumarate SCHEMBL3956267 | 0.97 | HCAR2 (0.61) | TSHRHPGDHCAR2THRBATM | |
| Styrene SCHEMBL8094670 | 0.95 | HCAR2 (0.58) | TSHRHPGDHCAR2THRBL3MBTL1 | |
| Styrene SCHEMBL8094673 | 0.95 | HCAR2 (0.58) | TSHRHPGDHCAR2THRBL3MBTL1 | |
| Styrene SCHEMBL1010365 | 0.94 | TSHR (0.63) | TSHRHPGDHCAR2THRBATM | |
| Styrene SCHEMBL67823 | 0.94 | TSHR (0.67) | TSHRHPGDHCAR2THRBATM | |
| Styrene SCHEMBL3196230 | 0.94 | TSHR (0.67) | TSHRHPGDHCAR2THRBATM | |
| Styrene SCHEMBL3696057 | 0.94 | TSHR (0.67) | TSHRHPGDHCAR2THRBATM | |
| Styrene SCHEMBL28887747 | 0.94 | TSHR (0.67) | TSHRHPGDHCAR2THRBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222435-B1 | METHOD FOR MANUFACTURING PRINTED MATTER | TORAY INDUSTRIES (JP) | 2021-11-24 | — | — | EP | disclosed |
| US-20170320312-A1 | METHOD FOR MANUFACTURING PRINTED MATTER | TORAY INDUSTRIES, INC. (JP) | 2017-11-09 | — | — | US | disclosed |
| EP-3222435-A1 | METHOD FOR MANUFACTURING PRINTED MATTER | Toray Industries, Inc. (JP) | 2017-09-27 | — | — | EP | disclosed |
| EP-0984331-B1 | Yellow toner, process for producing the toner and image forming method using the toner | CANON KK (JP) | 2006-07-19 | — | — | EP | disclosed |
| US-6187495-B1 | YELLOW TONER PARTICLES COMPRISING MIXTURE OF AN AZO ORGANIC PIGMENT AND AN AZO DYE DISPERSED IN A BINDER RESIN; LIGHTFASTNESS, CHARGEABILITY; ELECTROGRAPHY | CANON KABUSHIKI KAISHA (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0984331-A2 | Yellow toner, process for producing the toner and image forming method using the toner | CANON KABUSHIKI KAISHA (JP) | 2000-03-08 | — | — | EP | disclosed |
| US-5665506-A | SUSPENSION POLYMERIZATION; HIGH CHARGEABILITY AND DEFINITION | HODOGAYA CHEMICAL CO., LTD. (JP) | 1997-09-09 | — | — | US | disclosed |
| EP-0726501-A1 | Toner for the development of electrostatic image and process for the preparation thereof | HODOGAYA CHEMICAL CO LTD (JP) | 1996-08-14 | — | — | EP | disclosed |