⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044593 | 0.73 | ALDH1A1 (0.44) | — | |
| SCHEMBL11306264 | 0.73 | ALDH1A1 (0.44) | — | |
| SCHEMBL103330 | 0.71 | — | — | |
| N-Methyl-N-Nitrosurea SCHEMBL28025247 | 0.69 | ALDH1A1 (0.39) | — | |
| N-Methyl-N-Nitrosurea SCHEMBL38377 | 0.69 | — | — | |
| SCHEMBL8427528 | 0.69 | — | — | |
| SCHEMBL3500103 | 0.69 | — | — | |
| SCHEMBL22895 | 0.68 | — | — | |
| SCHEMBL128211 | 0.67 | — | — | |
| N-Methyl-N-Nitrosurea SCHEMBL28057965 | 0.67 | ALDH1A1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3940383-A | ANTICANCER | STANFORD RESEARCH INSTITUTE (US) | 1976-02-24 | — | — | US | claimed |
| US-20240239764-A1 | SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-07-18 | — | — | US | disclosed |
| US-20240150452-A1 | MULTIFUNCTIONAL PROTEIN MOLECULES COMPRISING DECORIN AND USE THEREOF | CATALENT PHARMA SOLUTIONS, LLC | 2024-05-09 | — | — | US | disclosed |
| US-20240083868-A1 | SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS | MEKANISTIC THERAPEUTICS, LLC | 2024-03-14 | — | — | US | disclosed |
| US-20240050415-A1 | DACLATASVIR FOR USE IN TREATING LUNG AND PROSTATE CANCER | HENRY FORD HEALTH SYSTEM (US) | 2024-02-15 | — | — | US | disclosed |
| US-11879009-B2 | Multifunctional protein molecules comprising decorin and use thereof | CATALENT PHARMA SOLUTIONS, LLC (US) | 2024-01-23 | — | — | US | disclosed |
| US-11746151-B2 | Compositions and methods for treating cancer | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-09-05 | — | — | US | disclosed |
| US-11673876-B2 | Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors | MEKANISTIC THERAPEUTICS LLC (US) | 2023-06-13 | — | — | US | disclosed |
| US-20220213054-A1 | SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS | MEKANISTIC THERAPEUTICS LLC (US) | 2022-07-07 | — | — | US | disclosed |
| US-11377488-B2 | Multifunctional protein molecules comprising decorin and use thereof | CATALENT PHARMA SOLUTIONS, LLC (US) | 2022-07-05 | — | — | US | disclosed |
| US-20090010878-A1 | Pulsatile dosing of gossypol for treatment of disease | ASCENTA THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | US | disclosed |
| US-20080253997-A1 | COMPOSITIONS AND METHODS FOR PROTECTING CELLS FROM TOXIC EXPOSURES | PERSCITUS BIOSCIENCES, LLC (US) | 2008-10-16 | — | — | US | disclosed |
| US-20080125430-A1 | NEW SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-05-29 | — | — | US | disclosed |
| US-20080095755-A1 | Methods and compositions for the treatment of cancer | QUINTESSENCE BIOSCIENCES, INC. (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080021095-A1 | Small Molecule Antagonists of Xiap Family Proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-01-24 | — | — | US | disclosed |
| US-20060247318-A1 | Small molecule inhibitors of STAT3 and the uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-11-02 | — | — | US | disclosed |
| US-20060211757-A1 | INHIBITORS OF MURINE DOUBLE MINUTE-2(MDM2) SUCH AS (2'R,3'S,4'R,5'R)6-CHLORO-4'-2,2-DIMETHYL-PROPYL-2'-(2,2-DIMETHYL-PROPYL)-2-OXO-1,2-DIHYDRO-SPIRO[INDOLE-3,3'-PYRROLIDINE]-5'-CARBOXYLIC ACID(3-MORPHOLIN-4-YL-PROPYL)-AMIDE, USED FOR INDUCING APOPTOSIS AND CELL CYCLE ARREST; ANTIPROLIFERATIVE AGENTS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-09-21 | — | — | US | disclosed |
| US-20050261232-A1 | Non-natural ribonuclease conjugates as cytotoxic agents | QUINTESSENCE BIOSCIENCES, INC. (US) | 2005-11-24 | — | — | US | disclosed |
| US-20050058725-A1 | Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent | MCKEARN JOHN P (US) | 2005-03-17 | — | — | US | disclosed |
| US-3940383-A | ANTICANCER | STANFORD RESEARCH INSTITUTE (US) | 1976-02-24 | — | — | US | disclosed |