Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 9/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23301036 | 0.92 | PRKCZ (0.50) | PRKCZPIM1PIM2ROCK2CCR2 | |
| SCHEMBL29897364 | 0.92 | PRKCZ (0.50) | PRKCZPIM1PIM2ROCK2CCR2 | |
| SCHEMBL25043929 | 0.88 | ABL1 (0.42) | PRKCZPIM1PIM2EHMT2ABL1 | |
| SCHEMBL23301223 | 0.83 | PRKCZ (0.58) | PRKCZROCK2CCR2ROCK1PRKD2 | |
| SCHEMBL29897353 | 0.83 | PRKCZ (0.58) | PRKCZROCK2CCR2ROCK1PRKD2 | |
| SCHEMBL23328348 | 0.82 | DYRK1A (0.46) | PRKCZGPR119DYRK1ABTKEPHX2 | |
| SCHEMBL25043928 | 0.82 | PIK3CD (0.44) | PIM1PIM2ABL1HDAC1HDAC2 | |
| SCHEMBL25044178 | 0.82 | PIK3CD (0.44) | PIM1PIM2ABL1HDAC1HDAC2 | |
| SCHEMBL23301073 | 0.81 | PRKCZ (0.54) | PRKCZABL1ROCK2CCR2ROCK1 | |
| SCHEMBL23328190 | 0.80 | USP30 (0.43) | PRKCZPIM1PIM2ABL1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230045929-A1 | ISOQUINOLINE DERIVATIVES AS SIK2 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230045929-A1 | ISOQUINOLINE DERIVATIVES AS SIK2 INHIBITORS | SIK2, SIK3, SIK1 | PRKCZ 875/4885PIM1 1089/4885PIM2 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.