SCHEMBL25047701

SCHEMBL25047701

CC(C)(C)OC(=O)NC[C@H]1C[C@@H](n2cc(I)c3c(Cl)nc(Cl)nc32)[C@@H]2OC(C)(C)O[C@H]12

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ACACB O00763 1/20 0.31
▸ ACACA Q13085 1/20 0.31
▸ GFER P55789 1/20 0.30
▸ STK17B O94768 1/20 0.30
▸ STK17A Q9UEE5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25048253 0.92 ADORA2A (0.30) —
SCHEMBL31617917 0.90 HRH2 (0.31) ACACBACACASTK17BSTK17A
SCHEMBL31618010 0.89 ADK (0.39) GFER
SCHEMBL30941089 0.88 HRH2 (0.31) —
SCHEMBL30940981 0.84 ADORA2A (0.30) —
SCHEMBL30941110 0.82 ADK (0.42) —
SCHEMBL31617974 0.80 STK17B (0.37) ACACBACACASTK17BSTK17A
SCHEMBL25048554 0.80 — —
SCHEMBL31617962 0.79 METTL3 (0.38) —
SCHEMBL30941177 0.79 ADK (0.33) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250188110-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2025-06-12 — — US disclosed
WO-2023017152-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2023-02-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250188110-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION KMT5A, KMT5B, KMT5C ACACB 3813/4885ACACA 3853/4885GFER 4105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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