SCHEMBL25048847

SCHEMBL25048847

COc1cc(OC)cc([C@H]2C[C@@H](n3cc(Br)c4c(N)nc(Cl)nc43)[C@@H]3OC(C)(C)O[C@@H]32)c1

nearest known ligand 0.34

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ METTL3 Q86U44 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25047760 0.92 METTL3 (0.35) METTL3
SCHEMBL30941728 0.92 METTL3 (0.35) METTL3
SCHEMBL30941554 0.92 METTL3 (0.35) METTL3
SCHEMBL25048451 0.91 — —
SCHEMBL25048489 0.84 PRMT5 (0.34) METTL3
SCHEMBL30940742 0.83 HTR2A (0.32) METTL3
SCHEMBL25048303 0.83 HTR2A (0.32) METTL3
SCHEMBL25046787 0.83 METTL3 (0.45) METTL3
SCHEMBL30940841 0.82 CHKA (0.31) —
SCHEMBL25049313 0.81 METTL3 (0.36) METTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023017152-A1 SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) 2023-02-16 — — WO disclosed
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