Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.36 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.35 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.35 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.34 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25049350 | 0.96 | IGF1R (0.38) | IGF1RPRMT5NAE1CA2GRK5 | |
| SCHEMBL31618056 | 0.89 | PRMT5 (0.43) | PRMT5WDR77METTL3 | |
| SCHEMBL31618015 | 0.84 | PRMT5 (0.44) | PRMT5WDR77METTL3 | |
| SCHEMBL25048261 | 0.83 | IGF1R (0.36) | IGF1RPRMT5LCKSRCKDR | |
| SCHEMBL31618039 | 0.83 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL25047809 | 0.83 | PRMT5 (0.41) | PRMT5WDR77 | |
| SCHEMBL31618087 | 0.81 | PRMT5 (0.49) | PRMT5WDR77METTL3 | |
| SCHEMBL25048258 | 0.81 | PRMT5 (0.49) | PRMT5WDR77METTL3 | |
| SCHEMBL25048777 | 0.80 | PRMT5 (0.41) | PRMT5FDFT1WDR77METTL3 | |
| SCHEMBL25049352 | 0.79 | PRMT5 (0.42) | PRMT5FDFT1WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017152-A1 | SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2023-02-16 | — | — | WO | disclosed |