Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 9/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.34 |
| ▸ | IL6 | P05231 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31617999 | 0.90 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL25049354 | 0.86 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL25046612 | 0.84 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL25047461 | 0.81 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL25046633 | 0.81 | PIP4K2A (0.38) | PRMT5WDR77PIP4K2AIL6TLR7 | |
| SCHEMBL25046632 | 0.79 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL25049348 | 0.78 | IGF1R (0.37) | PRMT5WDR77NAE1 | |
| SCHEMBL23120385 | 0.78 | PRMT5 (0.33) | PRMT5WDR77 | |
| SCHEMBL23120235 | 0.77 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL25049350 | 0.73 | IGF1R (0.38) | PRMT5WDR77NAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017152-A1 | SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2023-02-16 | — | — | WO | disclosed |