Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 14/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 14/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | IL6 | P05231 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25046632 | 0.87 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL25046612 | 0.82 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL25049354 | 0.82 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL25048261 | 0.82 | IGF1R (0.36) | PIP4K2APRMT5WDR77 | |
| SCHEMBL25047713 | 0.82 | PRMT5 (0.41) | PIP4K2APRMT5WDR77 | |
| SCHEMBL25049349 | 0.81 | PRMT5 (0.35) | PIP4K2APRMT5WDR77CCNA2CDK2 | |
| SCHEMBL25048329 | 0.80 | PRMT5 (0.40) | PIP4K2APRMT5WDR77JAK2JAK1 | |
| SCHEMBL25048728 | 0.80 | PRMT5 (0.39) | PIP4K2APRMT5WDR77JAK2JAK1 | |
| SCHEMBL31617999 | 0.78 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL25046638 | 0.76 | PRMT5 (0.38) | PIP4K2APRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017152-A1 | SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2023-02-16 | — | — | WO | disclosed |