Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13832208 | 0.84 | CDK7 (0.61) | IGF1RCDK7CDK9EGFRALK | |
| SCHEMBL29833319 | 0.84 | CDK7 (0.61) | IGF1RCDK7CDK9EGFRALK | |
| SCHEMBL30173407 | 0.84 | IGF1R (0.49) | IGF1RCDK7CDK9EGFRALK | |
| SCHEMBL13832181 | 0.84 | IGF1R (0.49) | IGF1RCDK7CDK9EGFRALK | |
| SCHEMBL30428996 | 0.81 | MAP4K1 (0.50) | IGF1RCDK7CDK9EGFRALK | |
| SCHEMBL28996954 | 0.81 | MAP4K1 (0.50) | IGF1RCDK7CDK9EGFRALK | |
| SCHEMBL25056485 | 0.77 | IGF1R (0.50) | IGF1RCDK7CDK9EGFRALK | |
| SCHEMBL26506792 | 0.77 | ULK1 (0.55) | IGF1RCDK7CDK9ALKMAPK8 | |
| SCHEMBL13832185 | 0.77 | ALK (0.56) | IGF1REGFRALKINSRMAP4K1 | |
| SCHEMBL25637977 | 0.76 | JAK1 (0.35) | IGF1RCDK7CDK9EGFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4137484-A1 | TRICYCLIC COMPOUNDS AS EGFR INHIBITORS | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-02-22 | — | — | EP | disclosed |