Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.37 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6132431 | 0.79 | HPGD (0.45) | HPGDPDE4DPDE4APDE4BPDE4C | |
| SCHEMBL21871395 | 0.78 | HPGD (0.49) | CHRM1HPGDGPR119RECQLEPHX1 | |
| SCHEMBL21871866 | 0.76 | HPGD (0.47) | HPGDGPR119RECQLEPHX1 | |
| SCHEMBL18609897 | 0.76 | HPGD (0.47) | HPGDGPR119RECQLEPHX1 | |
| SCHEMBL31286764 | 0.75 | HPGD (0.44) | CHRM1HPGDGPR119RECQLEPHX1 | |
| SCHEMBL310354 | 0.75 | HPGD (0.51) | CHRM1HPGDGPR119RECQLEPHX1 | |
| SCHEMBL1085082 | 0.75 | HPGD (0.51) | CHRM1HPGDGPR119RECQLEPHX1 | |
| SCHEMBL14480194 | 0.75 | RECQL (0.52) | CHRM1HPGDGPR119RECQLEPHX1 | |
| SCHEMBL9032915 | 0.75 | RECQL (0.52) | HPGDGPR119RECQLEPHX1PRMT5 | |
| SCHEMBL1795814 | 0.75 | HPGD (0.46) | CHRM1HPGDGPR119RECQLEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-B1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS INC (US) | 2023-02-22 | — | — | EP | disclosed |