Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 14/20 | 0.87 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.66 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.66 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.62 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.62 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18837471 | 0.98 | LTA4H (0.84) | LTA4HCHRNB2CHRNA4PSMB1PSMB5 | |
| SCHEMBL7139563 | 0.87 | LTA4H (1.00) | LTA4HPSMB1PSMB5PSMB2HRH3 | |
| SCHEMBL20553175 | 0.83 | LTA4H (1.00) | LTA4HCHRNB2CHRNA4PSMB1PSMB5 | |
| SCHEMBL20553176 | 0.83 | LTA4H (1.00) | LTA4HCHRNB2CHRNA4PSMB1PSMB5 | |
| SCHEMBL255201 | 0.81 | LTA4H (0.86) | LTA4HPSMB1PSMB5HRH3KDM4E | |
| SCHEMBL12050716 | 0.80 | HRH3 (0.82) | LTA4HHRH3 | |
| SCHEMBL7411609 | 0.80 | CHRNB2 (1.00) | LTA4HCHRNB2CHRNA4PTGS2 | |
| SCHEMBL3951411 | 0.79 | LTA4H (0.83) | LTA4HPSMB1PSMB5PSMB2HRH3 | |
| SCHEMBL3578646 | 0.79 | HRH3 (0.90) | LTA4HPSMB1PSMB5PSMB2HRH3 | |
| Ammonia Solution, Strong SCHEMBL264615 | 0.79 | LTA4H (0.83) | LTA4HPSMB1PSMB5HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |