Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17303977 | 0.79 | PDE10A (0.45) | PDE10AHPGD | |
| SCHEMBL15830313 | 0.75 | SYK (0.38) | CTSKPDE10AMKNK1MKNK2CCNT1 | |
| SCHEMBL18672971 | 0.75 | CTSK (0.38) | CTSKPDE10AMKNK1MKNK2CCNT1 | |
| SCHEMBL21566709 | 0.75 | CCNT1 (0.47) | CTSKPDE10AMKNK1MKNK2CCNT1 | |
| SCHEMBL25390986 | 0.70 | NPC1 (0.46) | — | |
| SCHEMBL18284684 | 0.67 | MKNK1 (0.39) | CTSKPDE10AMKNK1MKNK2CCNT1 | |
| SCHEMBL28617770 | 0.67 | MALT1 (0.41) | CTSKLATS1MKNK1MKNK2CCNT1 | |
| SCHEMBL17151389 | 0.65 | ALDH1A1 (0.48) | CTSKPDE10AMKNK1MKNK2CCNT1 | |
| SCHEMBL19468965 | 0.63 | LATS1 (0.44) | LATS1MKNK1MKNK2CCNT1CDK9 | |
| SCHEMBL1155765 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |