Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | PTGFR | P43088 | 5/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2195 | 0.84 | LPAR1 (0.48) | LPAR1LPAR3LPAR2HDAC3HDAC1 | |
| SCHEMBL1651 | 0.80 | LPAR1 (0.39) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL1579 | 0.80 | LPAR1 (0.39) | LPAR1LPAR3LPAR2HDAC3HDAC1 | |
| SCHEMBL2106 | 0.79 | MAPT (0.39) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL1166 | 0.79 | LPAR1 (0.47) | LPAR1LPAR3LPAR2HDAC3HDAC1 | |
| SCHEMBL2162 | 0.77 | P2RX7 (0.39) | LPAR1LPAR3LPAR2P2RX7MAPT | |
| SCHEMBL1733 | 0.76 | LPAR1 (0.37) | LPAR1LPAR3HDAC1HDAC8HDAC6 | |
| SCHEMBL6655 | 0.73 | MEN1 (0.42) | LPAR1LPAR3MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL2194 | 0.71 | LPAR1 (0.43) | LPAR1LPAR3LPAR2P2RX7MAPT | |
| SCHEMBL2296060 | 0.71 | LPAR1 (0.62) | LPAR1LPAR3LPAR2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |