Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 9/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22031993 | 1.00 | OPRK1 (0.49) | OPRK1ARCHUKKDM4EMEN1 | |
| SCHEMBL22031992 | 1.00 | OPRK1 (0.49) | OPRK1ARCHUKKDM4EMEN1 | |
| SCHEMBL20474638 | 0.89 | OPRK1 (0.42) | OPRK1ARCHUKKDM4EMEN1 | |
| SCHEMBL17387847 | 0.85 | OPRK1 (0.45) | OPRK1ARJAK2CHRNB2CHRNB4 | |
| SCHEMBL15971696 | 0.85 | OPRK1 (0.45) | OPRK1ARJAK2CHRNB2CHRNB4 | |
| SCHEMBL22996379 | 0.81 | OPRK1 (0.42) | OPRK1ARJAK2CHRNB2CHRNB4 | |
| SCHEMBL22996455 | 0.78 | CNR2 (0.50) | OPRK1ARKDM4EMEN1CASP1 | |
| SCHEMBL23754091 | 0.77 | CHRNB2 (0.41) | OPRK1ARJAK2CHRNB2CHRNB4 | |
| SCHEMBL29906538 | 0.77 | CHRNB2 (0.41) | OPRK1ARJAK2CHRNB2CHRNB4 | |
| SCHEMBL19343217 | 0.77 | CNR2 (0.52) | OPRK1ARKDM4EMEN1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230055250-A1 | MAP4K4 INHIBITORS | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230055250-A1 | MAP4K4 INHIBITORS | MAP4K4, MAP4K5, MAP4K1 | OPRK1 1785/4885AR 4061/4885CHUK 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.