Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | JAK1 | P23458 | 5/20 | 0.38 |
| ▸ | JAK3 | P52333 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20678878 | 0.82 | TYK2 (1.00) | TYK2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL25069960 | 0.78 | TYK2 (0.47) | TYK2RIPK2TLR8TGFBR1JAK2 | |
| SCHEMBL20697093 | 0.72 | TYK2 (1.00) | TYK2HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL25069959 | 0.69 | TYK2 (0.40) | TYK2HTTGAAALDH1A1HPGD | |
| SCHEMBL25069986 | 0.66 | SMN1; SMN2 (0.42) | TYK2HTTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL12681919 | 0.65 | JAK1 (0.58) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL27671223 | 0.65 | GAA (0.50) | TYK2HTTGAAHSD17B10KDM4E | |
| SCHEMBL20689058 | 0.64 | TYK2 (0.62) | TYK2RIPK2HTTHSD17B10KDM4E | |
| Acetic Acid SCHEMBL27671247 | 0.63 | RAB9A (0.49) | TYK2HTTGAAHSD17B10KDM4E | |
| SCHEMBL25070272 | 0.63 | TYK2 (0.39) | TYK2TLR8TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230056447-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230056447-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | TYK2 1/4885RIPK2 38/4885TLR8 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.