Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25069959 | 0.90 | TYK2 (0.40) | SMN1; SMN2ALDH1A1HPGDLMNATYK2 | |
| SCHEMBL25069960 | 0.88 | TYK2 (0.47) | ALDH1A1HPGDKDM4EHSD17B10MAPK1 | |
| SCHEMBL20689061 | 0.85 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL20689065 | 0.77 | TYK2 (0.53) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL21246137 | 0.77 | POLB (0.40) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL21258581 | 0.76 | TYK2 (0.52) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL20689058 | 0.75 | TYK2 (0.62) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL25069973 | 0.72 | CYP1A2 (0.43) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL25070271 | 0.71 | GPR119 (0.33) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL20696957 | 0.71 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230056447-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230056447-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | SMN1; SMN2 1145/4885ALDH1A1 4827/4885HPGD 4476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.