Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PPP5C | P53041 | 2/20 | 0.45 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.45 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.45 |
| ▸ | NPY4R | P50391 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25074346 | 1.00 | HTT (0.59) | HTTLMNANAMPTALDH1A1TSHR | |
| SCHEMBL14471382 | 1.00 | HTT (0.59) | HTTLMNANAMPTALDH1A1TSHR | |
| SCHEMBL8194135 | 0.90 | HTT (0.71) | HTTLMNAALDH1A1TSHRPOLB | |
| SCHEMBL3436956 | 0.89 | LMNA (0.69) | HTTLMNAALDH1A1TSHRPOLB | |
| SCHEMBL18390513 | 0.88 | HPGD (0.57) | HTTLMNANAMPTALDH1A1TSHR | |
| SCHEMBL26042922 | 0.88 | L3MBTL3 (0.52) | HTTLMNANAMPTALDH1A1TSHR | |
| SCHEMBL24207819 | 0.88 | L3MBTL3 (0.52) | HTTLMNANAMPTALDH1A1TSHR | |
| SCHEMBL26162910 | 0.87 | HTT (0.46) | HTTLMNANAMPTALDH1A1TSHR | |
| SCHEMBL16838101 | 0.85 | HTT (0.60) | HTTLMNAALDH1A1TSHRPOLB | |
| SCHEMBL12424259 | 0.85 | NAMPT (0.45) | HTTLMNANAMPTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023255-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-02-23 | — | — | WO | disclosed |