Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856469 | 0.84 | ALDH1A1 (0.55) | ALDH1A1KDM4ERAB9ANPC1CHEK1 | |
| SCHEMBL14856468 | 0.84 | ALDH1A1 (0.55) | ALDH1A1KDM4ERAB9ANPC1CHEK1 | |
| SCHEMBL26264014 | 0.82 | CRBN (0.61) | CRBN | |
| SCHEMBL14857155 | 0.79 | ALDH1A1 (0.68) | ALDH1A1KDM4ERAB9ANPC1CHEK1 | |
| SCHEMBL14857154 | 0.79 | ALDH1A1 (0.68) | ALDH1A1KDM4ERAB9ANPC1CHEK1 | |
| SCHEMBL14856480 | 0.77 | ALDH1A1 (0.55) | ALDH1A1KDM4ERAB9ANPC1CHEK1 | |
| SCHEMBL14857374 | 0.77 | ALDH1A1 (0.55) | ALDH1A1KDM4ERAB9ANPC1CHEK1 | |
| SCHEMBL14856776 | 0.76 | RAB9A (0.64) | ALDH1A1KDM4ERAB9ANPC1HPGDS | |
| SCHEMBL14856775 | 0.76 | RAB9A (0.64) | ALDH1A1KDM4ERAB9ANPC1HPGDS | |
| SCHEMBL14856205 | 0.75 | ALDH1A1 (0.62) | ALDH1A1KDM4ERAB9ANPC1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023177451-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF CYCLIN DEPENDENT KINASES | EnhancedBio Inc. (KR) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |