Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | STK4 | Q13043 | 1/20 | 0.34 |
| ▸ | STK3 | Q13188 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26493919 | 0.86 | BTK (0.36) | BTKJAK2JAK1FFAR2LRRK2 | |
| SCHEMBL3533630 | 0.78 | JAK2 (0.52) | JAK2JAK1 | |
| SCHEMBL19004855 | 0.71 | BTK (0.40) | BTKJAK2JAK1FFAR2PDE10A | |
| SCHEMBL26496338 | 0.70 | USP7 (0.41) | BTKJAK2JAK1FFAR2LRRK2 | |
| SCHEMBL21416115 | 0.69 | KDM4E (0.41) | FFAR2MAP4K4ADORA2A | |
| SCHEMBL26493925 | 0.68 | BTK (0.41) | BTKKHK | |
| SCHEMBL12590817 | 0.66 | RAB9A (0.48) | JAK2JAK1FFAR2CHRM4PDE10A | |
| SCHEMBL30977957 | 0.64 | LRRK2 (0.41) | BTKJAK2JAK1CHRM4LRRK2 | |
| SCHEMBL12561873 | 0.64 | JAK2 (0.61) | JAK2JAK1CSF1R | |
| SCHEMBL14241098 | 0.64 | AURKA (0.49) | JAK2JAK1FFAR2CHRM4STK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |