Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 13/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 10/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29169174 | 1.00 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL1015082 | 0.88 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL29168988 | 0.84 | HTR2C (0.41) | HSD17B10HTR2CHTR2A | |
| SCHEMBL29168986 | 0.84 | HTR2C (0.41) | HSD17B10HTR2CHTR2A | |
| SCHEMBL14527151 | 0.80 | HTR2C (0.63) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL29169075 | 0.78 | LMNA (0.56) | KDM4EALDH1A1SMN1; SMN2LOXL2MAPT | |
| SCHEMBL25075523 | 0.78 | LMNA (0.56) | KDM4EALDH1A1SMN1; SMN2LOXL2MAPT | |
| SCHEMBL29168967 | 0.77 | KDM4E (0.41) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL29168963 | 0.77 | KDM4E (0.41) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL12180387 | 0.77 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117377665-A | PARP7 inhibitor and application thereof | 北京华森英诺生物科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023020479-A1 | PARP7 INHIBITOR AND APPLICATION THEREOF | 重庆华森制药股份有限公司 | 2023-02-23 | — | — | WO | disclosed |