Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 8/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25075204 | 0.93 | NPC1 (0.50) | GNAI3GNAO1GNAI1NPC1KDM1A | |
| SCHEMBL25075141 | 0.92 | GNAI3 (0.44) | GNAI3GNAO1GNAI1NPC1ITGB3 | |
| SCHEMBL26494080 | 0.89 | NPC1 (0.45) | GNAI3GNAO1GNAI1NPC1KDM1A | |
| SCHEMBL26494145 | 0.86 | NPC1 (0.46) | GNAI3GNAO1GNAI1NPC1KDM1A | |
| SCHEMBL2603225 | 0.86 | L3MBTL1 (0.49) | GNAI3GNAO1GNAI1NPC1L3MBTL1 | |
| SCHEMBL26494350 | 0.86 | NPC1 (0.46) | GNAI3GNAO1GNAI1NPC1KDM1A | |
| SCHEMBL25075318 | 0.86 | NPC1 (0.46) | GNAI3GNAO1GNAI1NPC1KDM1A | |
| SCHEMBL25075138 | 0.84 | NPC1 (0.43) | GNAI3GNAO1GNAI1NPC1ITGB3 | |
| SCHEMBL26494363 | 0.84 | NPC1 (0.43) | GNAI3GNAO1GNAI1NPC1ITGB3 | |
| SCHEMBL26494158 | 0.84 | NPC1 (0.43) | GNAI3GNAO1GNAI1NPC1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |