Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 6/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856668 | 0.88 | CNR2 (0.36) | CNR2TRPV1FAAHP2RX7LMNA | |
| SCHEMBL14856808 | 0.87 | CNR2 (0.38) | CNR2HTR2AHTR2CTRPV1FAAH | |
| SCHEMBL14856623 | 0.87 | CNR2 (0.37) | CNR2HTR2AHTR2CTRPV1FAAH | |
| SCHEMBL2810744 | 0.87 | PROKR1 (0.40) | CNR2HTR2AHTR2CPROKR1ROS1 | |
| SCHEMBL14856721 | 0.87 | CNR2 (0.38) | CNR2TRPV1FAAHP2RX7 | |
| SCHEMBL14856464 | 0.87 | CNR2 (0.35) | CNR2TRPV1FAAHP2RX7 | |
| SCHEMBL14856247 | 0.87 | CNR2 (0.36) | CNR2HTR2AHTR2CTRPV1FAAH | |
| SCHEMBL14856723 | 0.87 | CNR2 (0.36) | CNR2PROKR1TRPV1FAAHP2RX7 | |
| SCHEMBL14857251 | 0.87 | CNR2 (0.36) | CNR2TRPV1FAAHP2RX7LMNA | |
| SCHEMBL14856769 | 0.86 | CNR2 (0.36) | CNR2TRPV1FAAHP2RX7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |