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SCHEMBL25077053

SCHEMBL25077053

CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OC[C@@]1(C)O[C@@H](c2ccc3c(N)ncnn23)[C@H](O)[C@@H]1O)OCc1ccc(C#N)nc1

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ POLRMT O00411 1/20 0.41
▸ AKT1 P31749 5/20 0.31
▸ AKT2 P31751 4/20 0.31
▸ AKT3 Q9Y243 4/20 0.31
▸ PIK3R1 P27986 3/20 0.31
▸ PIK3CA P42336 3/20 0.31
▸ PLCG2 P16885 1/20 0.31
▸ GAB1 Q13480 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25764808 1.00 POLRMT (0.41) POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25766893 1.00 POLRMT (0.41) POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25766119 0.94 POLRMT (0.42) POLRMT
SCHEMBL25762079 0.93 POLRMT (0.41) POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25077289 0.93 POLRMT (0.41) POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25077177 0.93 POLRMT (0.41) POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25076981 0.92 POLRMT (0.42) POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25764867 0.92 POLRMT (0.41) POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25077262 0.92 POLRMT (0.41) POLRMTAKT1AKT2AKT3PIK3R1
SCHEMBL25077250 0.92 POLRMT (0.43) POLRMTAKT1AKT2AKT3PIK3R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023023527-A1 PHOSPHOLIPID COMPOUNDS AND METHODS OF MAKING AND USING THE SAME GILEAD SCIENCES, INC. (US) 2023-02-23 — — WO disclosed
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