SCHEMBL25077304

C=NC[C@]1(COP(=O)(O)OC[C@@H](COCc2cc(F)cc(C#N)c2)OCCCCCCCCCCCCCCCC)O[C@@H](c2ccc3c(N)ncnn23)[C@H](O)[C@@H]1O

nearest known ligand 0.39

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	POLRMT	O00411	1/20	0.39

▸	PLA2G10	O15496	2/20	0.30

▸	PLA2G1B	P04054	2/20	0.30

▸	PLA2G2A	P14555	2/20	0.30

▸	PLA2G5	P39877	2/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL25077355	0.96	POLRMT (0.39)	POLRMT
SCHEMBL25077613	0.96	POLRMT (0.39)	POLRMT
SCHEMBL25077225	0.96	POLRMT (0.39)	POLRMT
SCHEMBL25077379	0.93	POLRMT (0.40)	POLRMT
SCHEMBL25771709	0.93	POLRMT (0.40)	POLRMT
SCHEMBL25077003	0.93	POLRMT (0.40)	POLRMT
SCHEMBL25077320	0.93	POLRMT (0.40)	POLRMT
SCHEMBL25077233	0.93	POLRMT (0.40)	POLRMT
SCHEMBL25769244	0.90	POLRMT (0.40)	POLRMTPLA2G10PLA2G1BPLA2G2APLA2G5
SCHEMBL25077018	0.90	POLRMT (0.39)	POLRMTPLA2G10PLA2G1BPLA2G2APLA2G5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023023527-A1	PHOSPHOLIPID COMPOUNDS AND METHODS OF MAKING AND USING THE SAME	GILEAD SCIENCES, INC. (US)	2023-02-23	—	—	WO	disclosed