Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 5/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25079220 | 0.90 | HDAC1 (0.52) | HDAC1MEN1KMT2APOLBGPR55 | |
| SCHEMBL30257492 | 0.84 | PTPN1 (0.43) | POLBMAPTNPSR1 | |
| SCHEMBL2566299 | 0.84 | HDAC1 (0.58) | HDAC1MEN1KMT2ASPHK2SPHK1 | |
| SCHEMBL26641260 | 0.83 | FFAR4 (0.39) | HDAC1 | |
| SCHEMBL31248947 | 0.82 | HDAC1 (0.45) | HDAC1MEN1KMT2APOLBGPR55 | |
| SCHEMBL31248643 | 0.82 | HDAC1 (0.43) | HDAC1MEN1KMT2APOLBGPR55 | |
| SCHEMBL25821509 | 0.82 | FFAR4 (0.43) | HDAC1FAAH | |
| SCHEMBL31248684 | 0.79 | MEN1 (0.42) | HDAC1MEN1KMT2APOLBGPR55 | |
| SCHEMBL17136480 | 0.78 | HDAC1 (0.65) | HDAC1MEN1KMT2ANTSR1MAPT | |
| SCHEMBL31467422 | 0.78 | CYP2C9 (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023531-A1 | ESTROGEN RECEPTOR DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |