Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.57 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.57 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.57 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30257502 | 0.99 | TPSAB1 (0.56) | TPSAB1TPSD1TPSG1CRBNDDB1 | |
| SCHEMBL24754830 | 0.87 | CRBN (0.56) | TPSAB1TPSD1TPSG1CRBNDDB1 | |
| SCHEMBL30257050 | 0.83 | CRBN (0.59) | CRBNDDB1POLBALK | |
| SCHEMBL24548308 | 0.81 | CRBN (0.67) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL24491364 | 0.81 | CRBN (0.67) | CRBNDDB1POLBLMNAMAPT | |
| SCHEMBL24754196 | 0.80 | CRBN (0.52) | CRBNDDB1POLB | |
| SCHEMBL24548186 | 0.80 | CRBN (0.66) | CRBNDDB1POLBL3MBTL1LMNA | |
| SCHEMBL31232873 | 0.79 | CRBN (0.52) | CRBNDDB1POLBL3MBTL1HPGD | |
| SCHEMBL30256859 | 0.78 | CRBN (0.56) | TPSAB1TPSD1TPSG1CRBNDDB1 | |
| SCHEMBL24847990 | 0.78 | CRBN (0.75) | CRBNDDB1POLBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023531-A1 | ESTROGEN RECEPTOR DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |
| WO-2023023531-A1 | ESTROGEN RECEPTOR DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |