Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.38 |
| ▸ | WNT1 | P04628 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.35 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.35 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.33 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.33 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25079791 | 0.89 | CCR6 (0.44) | DYRK1AWNT1CCR6 | |
| SCHEMBL25079907 | 0.83 | CCR6 (0.52) | HTR6CCR6 | |
| SCHEMBL25079510 | 0.78 | MAP3K12 (0.42) | DYRK1APAK1CCR6 | |
| SCHEMBL25079719 | 0.77 | CCR6 (0.45) | DYRK1AWNT1CCR6 | |
| SCHEMBL25079902 | 0.77 | CCR6 (0.45) | DYRK1AWNT1CCR6 | |
| SCHEMBL25079903 | 0.77 | CCR6 (0.45) | DYRK1AWNT1CCR6 | |
| SCHEMBL25079573 | 0.74 | KIF11 (0.50) | — | |
| SCHEMBL25079785 | 0.73 | CCR6 (0.65) | CCR6 | |
| SCHEMBL30284751 | 0.73 | CCR6 (0.65) | CCR6 | |
| SCHEMBL31155642 | 0.73 | CCR6 (0.49) | CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023534-A2 | ARYL SULFONYL COMPOUNDS AS CCR6 INHIBITORS | CHEMOCENTRYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |