Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.76 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | RAF1 | P04049 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30254277 | 1.00 | KRAS (0.76) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25080921 | 0.94 | KRAS (0.67) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31323012 | 0.94 | KRAS (0.67) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL24857358 | 0.93 | KRAS (0.81) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30254167 | 0.93 | KRAS (0.67) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL24712081 | 0.93 | KRAS (0.65) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30254106 | 0.93 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25081184 | 0.93 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25080934 | 0.93 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL27191161 | 0.93 | KRAS (0.83) | KRASMAPK3MAPK1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347589-A2 | PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS CAPABLE OF INHIBITING KRAS MUTANT PROTEINS | Redx Pharma Plc (GB) | 2024-04-10 | — | — | EP | disclosed |
| WO-2023020519-A1 | 1, 4-OXAZEPANE DERIVATIVES AND USES THEREOF | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-02-23 | — | — | WO | disclosed |