SCHEMBL2508286

SCHEMBL2508286

CCCc1cc(C)c(OC(=O)c2ccccc2)c(OC(=O)c2ccccc2)c1C

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPARG P37231 5/20 0.46
PPARA Q07869 5/20 0.46
LMNA P02545 3/20 0.43
MAPT P10636 3/20 0.43
GAA P10253 2/20 0.43
POLB P06746 1/20 0.43
KMT2A Q03164 6/20 0.42
ALDH1A1 P00352 1/20 0.42
MEN1 O00255 2/20 0.39
PKM P14618 1/20 0.39
SREBF2 Q12772 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2502948 0.92 LMNA (0.41) PPARGPPARALMNAMAPTGAA
SCHEMBL27182057 0.91 LMNA (0.41) PPARGPPARALMNAMAPTGAA
SCHEMBL30035759 0.91 LMNA (0.41) PPARGPPARALMNAMAPTGAA
SCHEMBL2502638 0.90 PPARG (0.45) PPARGPPARALMNAMAPTGAA
SCHEMBL2504726 0.90 MAPT (0.46) LMNAMAPTGAAPOLBKMT2A
SCHEMBL2886746 0.89 PPARG (0.46) PPARGPPARALMNAMAPTGAA
SCHEMBL2505873 0.89 LMNA (0.43) PPARGPPARALMNAMAPTGAA
SCHEMBL2504096 0.89 PPARG (0.46) PPARGPPARALMNAMAPTGAA
SCHEMBL2509827 0.86 PPARG (0.44) PPARGPPARALMNAMAPTGAA
SCHEMBL2479731 0.86 MAPT (0.43) PPARGPPARALMNAMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2376423-A1 PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS Dow Global Technologies LLC (US) 2011-10-19 EP disclosed
WO-2010078519-A1 PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS DOW GLOBAL TECHNOLOGIES INC. (US) 2010-07-08 WO disclosed