Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 8/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 8/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25084838 | 0.86 | TGFBR1 (0.34) | CSNK1DCSNK1ETGFBR1MAPK14MAPK13 | |
| SCHEMBL25085150 | 0.86 | PDCD1 (0.37) | PDCD1CD274CSNK1DCSNK1ETGFBR1 | |
| SCHEMBL25084960 | 0.85 | PDCD1 (0.38) | PDCD1CD274CSNK1DCSNK1ETGFBR1 | |
| SCHEMBL25084881 | 0.85 | TGFBR1 (0.36) | CSNK1DCSNK1ETGFBR1MAPK14MAPK13 | |
| SCHEMBL25085008 | 0.83 | TGFBR1 (0.34) | CSNK1DCSNK1ETGFBR1MAPK14MAPK13 | |
| SCHEMBL25084622 | 0.81 | CHRNB2 (0.41) | TGFBR1TGFBR2IGF1RMAPK14MAPK13 | |
| SCHEMBL30156074 | 0.81 | CHRNB2 (0.41) | TGFBR1TGFBR2IGF1RMAPK14MAPK13 | |
| SCHEMBL25084927 | 0.81 | TLR9 (0.40) | PDCD1CD274TGFBR1TLR9TLR8 | |
| SCHEMBL25085115 | 0.80 | PDCD1 (0.38) | PDCD1CD274TGFBR1TLR9TLR8 | |
| SCHEMBL25084498 | 0.79 | TGFBR1 (0.39) | CSNK1DCSNK1ETGFBR1IGF1RMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11590116-B2 | Substituted pyridines and methods of use | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-02-28 | — | — | US | disclosed |
| US-11590116-B2 | Substituted pyridines and methods of use | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11590116-B2 | Substituted pyridines and methods of use | ALK, ACVR1, ACVR2A | PDCD1 3348/4885CD274 3380/4885CSNK1D 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.