Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.52 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9003193 | 0.82 | KMT2A (0.76) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL13326955 | 0.78 | KMT2A (1.00) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL5528147 | 0.78 | PIK3CA (0.47) | NPSR1PIK3CAPOLBKDM4EALDH1A1 | |
| SCHEMBL9640164 | 0.78 | KMT2A (0.69) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL9640988 | 0.78 | KMT2A (0.69) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL9639621 | 0.76 | KMT2A (0.67) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL22169012 | 0.76 | HTT (0.45) | KMT2AHRH4PIK3CAKDM4EALDH1A1 | |
| SCHEMBL13166826 | 0.75 | CYP2C19 (0.58) | KMT2AGAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1123583 | 0.75 | KMT2A (0.65) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL1123990 | 0.75 | KMT2A (0.65) | KMT2ANPSR1HRH4PIK3CAMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KUMQUAT BIOSCIENCES INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KUMQUAT BIOSCIENCES INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20230064360-A1 | HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. | 2023-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KRAS, NRAS, BRAF | KMT2A 4174/4885NPSR1 3380/4885HRH4 1890/4885 |
| US-20230064360-A1 | HETEROCYCLES AND USES THEREOF | KRAS, HRAS, TP53 | KMT2A 2806/4885NPSR1 3358/4885HRH4 2035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.