Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25088953 | 1.00 | NR1H2 (0.41) | NR1H2USP2SMN1; SMN2HTTATM | |
| SCHEMBL21696862 | 0.90 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2HTTATM | |
| SCHEMBL16132815 | 0.88 | P2RX7 (0.45) | NR1H2USP2SMN1; SMN2HTTATM | |
| SCHEMBL15110168 | 0.84 | HTT (0.42) | NR1H2USP2SMN1; SMN2HTTATM | |
| SCHEMBL8399546 | 0.79 | P2RX7 (0.53) | NR1H2HTTATMESR2MAPT | |
| SCHEMBL25422301 | 0.78 | USP2 (0.47) | NR1H2USP2SMN1; SMN2ESR2MAPT | |
| SCHEMBL23722977 | 0.78 | MAPK1 (0.41) | NR1H2USP2SMN1; SMN2HTTATM | |
| SCHEMBL23722978 | 0.78 | MAPK1 (0.41) | NR1H2USP2SMN1; SMN2HTTATM | |
| SCHEMBL15342771 | 0.78 | ALDH1A1 (0.45) | NR1H2SMN1; SMN2HTTATMESR2 | |
| SCHEMBL2393299 | 0.77 | ALDH1A1 (0.44) | NR1H2HTTATMESR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023942-A1 | HPK1 INHIBITORS, COMPOSITIONS COMPRISING HPK1 INHIBITOR, AND METHODS OF USING THE SAME | BIOFRONT LTD (CAYMAN) (KY) | 2023-03-02 | — | — | WO | disclosed |