Curcumin

Curcumin

SCHEMBL250984

COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O.COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 10/20 1.00
MAPT P10636 9/20 1.00
BACE1 P56817 5/20 1.00
MMP9 P14780 4/20 1.00
NFKB1 P19838 3/20 1.00
CYP2D6 P10635 2/20 1.00
CYP2C9 P11712 2/20 1.00
TSHR P16473 2/20 1.00
HSD17B10 Q99714 2/20 1.00
ABCB1 P08183 2/20 1.00
AKR1B1 P15121 2/20 1.00
MAOA P21397 2/20 1.00
MAOB P27338 2/20 1.00
HDAC3 O15379 2/20 1.00
HDAC1 Q13547 2/20 1.00
HDAC2 Q92769 2/20 1.00
HDAC6 Q9UBN7 2/20 1.00
ALOX5 P09917 2/20 1.00
STAT3 P40763 2/20 1.00
NFKB2 Q00653 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Curcumin SCHEMBL29876635 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL2804734 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL29360171 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL17629819 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL6901740 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL29358937 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL17629818 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL8336603 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL8440 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1
Curcumin SCHEMBL29355906 1.00 APP (1.00) APPMAPTBACE1MMP9NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107889884-A A kind of fresh lotus seeds become sour the control method of swollen bag 福建农林大学 2018-04-10 CN claimed
CN-102843919-B Method for masking curcumin flavor SAN-EI GEN F.F.I., INC. (JP) 2016-02-10 CN claimed
CN-103446057-B Oral curcumin nano-granule and preparation method thereof 1ST PEOPLES HOSPITAL CHANGZHOU 2014-12-31 CN claimed
CN-103446057-A Oral curcumin nano-granule and preparation method thereof 1ST PEOPLES HOSPITAL CHANGZHOU 2013-12-18 CN claimed
CN-117695229-B Shikonin curcumin liposome and preparation method and application thereof 广东润洁日化有限公司 2024-04-12 CN disclosed
CN-117695229-A Shikonin curcumin liposome and preparation method and application thereof 广东润洁日化有限公司 2024-03-15 CN disclosed
WO-2024013694-A1 COMPOSITIONS COMPRISING SURFACE MODIFIED GLOBULAR NANO-PARTICLES LANDA LABS (2012) LTD. (IL) 2024-01-18 WO disclosed
EP-4294418-A1 NOVEL ARTHRITIS EMULGEL COMPOSITION AND ITS PREPARATION PROCESS Lyrus Life Sciences Pvt. LTD. (IN) 2023-12-27 EP disclosed
US-11654119-B2 Bioavailable curcumin nanoparticles and methods of making NUTECH VENTURES (US) 2023-05-23 US disclosed
WO-2023047317-A1 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING INFLAMMATORY DISEASES INCLUDING DIABETES AND THYROID DISEASES ALKALAY RACHEL (IL) 2023-03-30 WO disclosed
CN-115154574-A Herbal Qingvoxel 王虹 2022-10-11 CN disclosed
CN-115154574-A Herbal Qingvoxel 王虹 2022-10-11 CN disclosed
CN-1993146-A Antibody-drug conjugates and methods GENENTECH INC (US) 2007-07-04 CN disclosed
CN-1923064-A Cut tobacco additive for safety type cigarettes and preparation method thereof CHEN CHUTING (CN) 2007-03-07 CN disclosed
CN-1736369-A Curcumin emulsion, its preparation process and use SHANDONG GREENERY NATURAL MEDI (CN) 2006-02-22 CN disclosed
US-20050010171-A1 Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract CURON MEDICAL, INC. 2005-01-13 US disclosed
WO-2002018654-A1 INDUCTION OF LDL RECEPTOR EXPRESSION BY EXTRACELLULAR-SIGNAL REGULATED KINASE, ERK-1/2 THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) 2002-03-07 WO disclosed
CN-1301535-A Use of curcumin to treat hepatitis B TIANJIA MEDICINE SCIENCE INST (CN) 2001-07-04 CN disclosed
US-5679864-A REACTING 2,4-DIKETONE WITH COMPLEXING AGENT TO PRODUCE ENOLIC REACTANT, ADDING AROMATIC ALDEHYDE, AMINE CATALYST, NEUTRALIZING GENE PRINT INC. (US) 1997-10-21 US disclosed
US-5447538-A Composition for dyeing hair comprising in admixture a non-exhausted vegetable powder, a direct dye and a solid diluent L'OREAL (FR) 1995-09-05 US disclosed